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可羅索(KL)多克隆抗體(生物素標記)

Biotin-Linked Polyclonal Antibody to Klotho (KL)

KLa; Klotho Alpha

  • 可羅索(KL)多克隆抗體(生物素標記) 產品包裝(模擬)
  • 可羅索(KL)多克隆抗體(生物素標記) 產品包裝(模擬)
  • Certificate 通過ISO 9001、ISO 13485質量體系認證

特異性

該抗體是針對KL的兔多克隆抗體。在免疫組織化學染色和免疫印跡實驗中能識別KL。

用法

Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.

儲存

經常使用則4°C保存。-20°C保存不超過兩年。避免反復凍融。

穩定性

熱穩定性以損失率顯示。損失率是由加速降解試驗決定,具體方法如下:在37°C孵育48小時,沒有顯著的降解或者沉淀產生。保質期內,在適當的條件下存儲,損失率低于5%。

贈品

相關產品

編號 適用物種:Mus musculus (Mouse,小鼠) 應用(僅供研究使用,不用于臨床診斷!)
RPH757Mu03 可羅索(KL)重組蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
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PAH757Mu02 可羅索(KL)多克隆抗體 WB; IHC; ICC; IP.
PAH757Mu01 可羅索(KL)多克隆抗體 WB; IHC; ICC; IP.
LAH757Mu71 可羅索(KL)多克隆抗體(生物素標記) WB; IHC; ICC.
LAH757Mu81 可羅索(KL)多克隆抗體(異硫氰酸熒光素標記) WB; IHC; ICC; IF.
SEH757Mu 可羅索(KL)檢測試劑盒(酶聯免疫吸附試驗法) Enzyme-linked immunosorbent assay for Antigen Detection.
WEH757Mu 可羅索(KL)檢測試劑盒(酶聯免疫吸附試驗法,寬范圍) Enzyme-linked immunosorbent assay for Antigen Detection.
SCH757Mu 可羅索(KL)檢測試劑盒(化學發光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
LMH757Mu 可羅索(KL)等多因子檢測試劑盒(流式熒光發光法) FLIA Kit for Antigen Detection.
KSH757Mu01 可羅索(KL)檢測試劑盒DIY材料(酶聯免疫吸附試驗法) 自己動手制作ELISA試劑盒的主要材料

參考文獻

雜志 參考文獻
Life Sciences High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature [Pubmed: 24012609]
EXPERIMENTAL & CLINICAL CARDIOLOGY Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in Mice [Com:Source]
Int J Clin Exp Pathol.? α-Klotho is an acute phase protein and altered by restraint stress in mice [Pubmed:Pmc4203207]
Annales de Biologie Clinique Les biomarqueurs des calcifications vasculaires [PubMed: 26069069]
Mol Med Rep Effect of secondary hyperparathyroidism serum on endothelial cells and intervention with Klotho [PubMed: 25873020]
Calcif Tissue Int Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a NewGALNT3 [PubMed: 25899975]
中華內分泌代謝雜志 抗衰老蛋白Klotho 阻斷高糖培養的大鼠腎小球系膜細胞TLR4/NF-κB p65/NGAL 通路的激活及其作用機制 [Cn: Article]
Mol Cell Endocrinol The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism [PubMed: 26419931]
Arch Med Sci Soluble Klotho protein as a novel serum biomarker in patients with acromegaly [pmc:PMC4754356]
Am J Nephrol Klotho?Deficiency?Aggravates?Tacrolimus-Induced?Renal?Injury?via?the?Phosphatidylinositol?3-Kinase-Akt-Forkhead?Box?Protein?O?Pathway [Pubmed:27174564]
Sci Rep. Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. [pubmed:28387374]
Nephrology Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management? [pubmed:28429560]
Journal of Integrative Nephrology & Andrology Associations between serum fibroblast growth factor 23 level and intradialytic hypotension in hemodialysis patients [issn:2394-2916]
International Journal of Clinical and Experimental Pathology Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in mice [ISSN:1936-2625]
Journal of veterinary medical science Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat model [pubmed:28943597]
Cellular Physiology and Biochemistry Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion Injury [Pubmed:29550818]
American Journal of Translational?Research Advanced maternal age impairs spatial learning capacity in young adult mouse offspring [Pubmed:29636887]
Journal of?Diabetes?and its?Complications Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complications [Pubmed:30042059]
Medical?Science?Monitor Klotho Inhibits Proliferation and Migration of Angiotensin II-Induced Vascular Smooth Muscle Cells (VSMCs) by Modulating NF-κB p65, Akt, and Extracellular Signal?… [Pubmed:30004089]
Nephrology Dialysis?Transplantation High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease [Pubmed: 30189026]
BMC?Nephrology The role of klotho in chronic kidney disease [Pubmed: 30348110]
Nature?Communications Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration [Pubmed: 30451844]
Kidney?International Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome [Pubmed: 30770217]
Expert?Opinion on?Therapeutic?Targets The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic rats [Pubmed: 30801205]
Mol Immunol CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection [Pubmed: 33223223]
Journal of Clinical Hypertension Effects of salt intervention on serum levels of Klotho influenced by salt sensitivity [Pubmed: 33164306]
CURRENT EYE RESEARCH Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats [Pubmed: 32744464]
international immunopharmacology Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats [Pubmed: 32438076]
Purinergic Signalling P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy. [Pubmed: 32377919]
Oxidative Medicine and Cellular Longevity Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury [Pubmed: 33123314]
NEUROSCIENCE Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia [Pubmed: 32612508]
Pharmacological Reports |áKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy [33675964]
J Mol Neurosci Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells [Pubmed:35112226]
Reproductive Biology and Endocrinology Expression of Klotho in Follicles of Patients With Polycystic Ovary Syndrome and Its Clinical Significance []
Journal of Ovarian Research Klotho is a prognostic indicator of oocytes qualities in polycystic ovary syndrome []
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